The C911 control uses the complement of bases 9 through 11 of the original siRNA. In our experiments, C911 controls maintain the off-target effects of the original sequence while eliminating the on-target effect of the siRNA, making it an ideal negative control to allow for experimental differentiation between on-target and off-target effects. For more deatils, see C911: A Bench-Level Control for Sequence Specific siRNA Off-Target Effects. If you have questions, feel free to contact me at firstname.lastname@example.org.
|Original Target||C911 Target||C911 Sense||C911 Antisense|